In the Book of Revelation, we marvel at the implication of taking the mark (666) as seen in Revelation 14:9-11, where such a person is condemned to eternal damnation unable to ever turn to the Lord as is available to most people still alive. However in Romans Chapter 1, the Bible also discusses the condition of people today, where as the scripture says three times because of their behavior, "The Lord game them over..."
Therefore God gave them over in the sinful desires of their hearts to sexual impurity for the degrading of their bodies with one another. Romans 1:24
Because of this, God gave them over to shameful lusts. Even their women exchanged natural sexual relations for unnatural ones. In the same way the men also abandoned natural relations with women and were inflamed with lust for one another. Romans 1:26-27
Furthermore, just as they did not think it worthwhile to retain the knowledge of God, so God gave them over to a depraved mind, so that they do what ought not to be done. Romans 1:28
We also saw examples of a person's actions causing God to reach his breaking point with them in the Old Testament:
“Their deeds do not permit them to return to their God. A spirit of prostitution is in their heart; they do not acknowledge the LORD. Hosea 5:4
I believe we are close to the time of the end spoken of in the Book of Revelation and as such, with the palpable rise of evil, wickedness and perversion in the world, we are seeing the result of many people in high positions (governmental, corporate, entertainment etc.) being "given over..." as it were. These are not stupid people, in fact by the world's standards, they are very smart, however there can be no other way to explain the wickedness that people in positions of influence and authority are inflicting on those who they "rule over". I believe many of these have in fact been "given over".